Role of let-7 family microRNA in breast cancer
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چکیده
منابع مشابه
Evolution of the let-7 microRNA Family
The increase of bodyplan complexity in early bilaterian evolution is correlates with the advent and diversification of microRNAs. These small RNAs guide animal development by regulating temporal transitions in gene expression involved in cell fate choices and transitions between pluripotency and differentiation. One of the two known microRNAs whose origins date back before the bilaterian ancest...
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MicroRNAs (miRNAs) are regulatory RNAs found in multicellular eukaryotes, including humans, where they are implicated in cancer. The let-7 miRNA times seam cell terminal differentiation in C. elegans. Here we show that the let-7 family negatively regulates let-60/RAS. Loss of let-60/RAS suppresses let-7, and the let-60/RAS 3'UTR contains multiple let-7 complementary sites (LCSs), restricting re...
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Innate immunity forms the first line of host defense. It is quick and usually shapes the adaptive immune responses which clear off the pathogens. However, dysregulated innate immune responses can lead to excessive inflammation which causes significant damage to the host. As a result, innate immune responses are tightly regulated. In this review, we focus on mechanisms by which microRNA let-7 re...
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Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy. RET/PTC rearrangement is the most common genetic modification identified in this category of cancer, increasing proliferation and dedifferentiation by the activation of the RET/PTC-RAS-BRAF-MAPK-ERK signaling pathway. Recently, let-7 miRNA was found to reduce RAS levels, acting as a tumor suppressor gene. Circulating miR...
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ژورنال
عنوان ژورنال: Non-coding RNA Research
سال: 2016
ISSN: 2468-0540
DOI: 10.1016/j.ncrna.2016.10.003